Analgesic / Antipyretic Drug Verapamil HCl CAS: 152-11-4 Anti-Hypertension
|FOB Price:||US $1-5 / Gram|
|Min. Order:||10 Gram|
|Min. Order||FOB Price|
|10 Gram||US $1-5/ Gram|
|Payment Terms:||T/T, Western Union, Paypal, Bitcoin|
- Model NO.: 152-11-4
- Customized: Non-Customized
- Suitable for: Adult
- Purity: >99%
- Delivery Time: 5-7 Hours
- Trademark: Steroid
- Specification: powder
- HS Code: 156793
- Powder: Yes
- Certification: ISO 9001, USP, BP
- State: Solid
- Shipping Time: Within 24 Hours
- Shipping Method: DHL, FedEx, TNT, Hkems, EMS
- Transport Package: Customized
- Origin: China
Product Name: (+/-)-Verapamil hydrochloride
Synonyms: R(+)-VERAPAMIL HYDROCHLORIDE;(+)-VERAPAMIL, METHOXY-, HYDROCHLORIDE;5-((3,4-dimethoxyphenethyl)methylamino)-2-(3,4-dimethoxyphenyl)-valeronitril;cordilox;d-365hydrochloride;finoptin;iproveratrilhydrochloride;izoptinhydrochloride
Product Categories: Miscellaneous Biochemicals;Organics;Calcium channel;Ion Channels;TYLENOL;antibiotic;Cardiovascular APIs mp 142 °C (dec.)(lit.)
storage temp. Refrigerator (+4°C)
solubility H2O: >30 mg/mL
Water Solubility soluble
Chemical Properties : White to off-white powder
Usage : analgesic, antipyretic
Usage : Bromhexine metabolite, sodium channel blocker, decongestent secretolytic agent for respiratory diseases.
|Product name||Verapamil HCL|
|CAS No.||152-11-4||Outer Packing||10kg/drum|
|Production date||2016/12/23||Shelf life||2 years|
|Items of analysis||Specification||Results|
|Infrared ectrophotometry:||should be positive||Complies|
|HPLC:||should be positive||Complies|
|Generally identify:||Show chloride reaction||Complies|
|(Description)||A white crystalline powder||Complies|
|(Loss on drying)||≤0.5% Not more than 0.5%||0.06%|
|(Residue on Ignition)||Not more than 0.1% n. m. t. 0.1%||0.06%|
|(Related substances)||Total impurity ≤0.5%, impurity is not more than 0.5%||0.08%|
|(Related substances)||Single impurity≤0.30% Not more than 0.30% of single impurity & the sum of all||0.04%|
|(Organic residual solvent)||Acetone<5000ppm,||Complies|
|(Organic residual solvent)||Toluene<890ppm||Complies|
|(Organic residual solvent)||Chloroform<60 ppm||Complies|
|(Assay)||C27H38N2O4·HCL Calculate on dried basis C27H38N2O4·HCL 99.0-101.0%||99.5%|
Verapamil Hydrochloride is the hydrochloride form of Verapamil, which is a phenylalkylamine calcium channel blocking agent. Verapamil inhibits the transmembrane influx of extracellular calcium ions into myocardial and vascular smooth muscle cells, causing dilatation of the main coronary and systemic arteries and decreasing myocardial contractility. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in some multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. (NCI04)
Verapamil is used for controlling ventricular rate in supraventricular tachycardia and migraine headache prevention.It is a class-IV antiarrhythmic and more effective than digoxin in controlling ventricular rate. Verapamil is not listed as a first line agent by the guidelines provided by JAMA in JNC-8.However, it may be used to treat hypertension if patient has co-morbid atrial fibrillation or other types of arrhythmia.
Verapamil is also used intra-arterially to treat cerebral vasospasm. Verapamil is used to treat the condition cluster headache.
Mechanism of Action:
Verapamil exerts antihypertensive effects by decreasing systemic vascular resistance, usually without orthostatic decreases in blood pressure or reflex tachycardia; bradycardia (rate less than 50 beats/min) is uncommon (1.4%). During isometric or dynamic exercise verapamil does not alter systolic cardiac function in patients with normal ventricular function.
Verapamil does not alter total serum calcium levels. However, one report suggested that calcium levels above the normal range may alter the therapeutic effect of verapamil.
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