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Domperidone, 57808-66-9, Pharmaceutical Raw material manufacturer / supplier in China, offering Pharmaceutical Raw Material Domperidone CAS 57808-66-9 for Anti-Emetic, Polypeptide Lyophilized Powder Gonadorelin for Body Growth 2mg/10mg/Vial, Lyophilized Powder Peptides Hexarelin Muscle Gain 2mg/Vial Hex Examorelin and so on.

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Supplier Homepage Product Pharmaceutical APIs Raw Material Pharmaceutical Raw Material Domperidone CAS 57808-66-9 for Anti-Emetic

Pharmaceutical Raw Material Domperidone CAS 57808-66-9 for Anti-Emetic

FOB Price: US $1 / g
Min. Order: 10 g
Min. Order FOB Price
10 g US $1/ g
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Port: Shenzhen, China
Production Capacity: 1500kg
Payment Terms: T/T, Western Union, Money Gram, Bitcoin

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Basic Info
  • Model NO.: CAS: 57808-66-9
  • Customized: Customized
  • Suitable for: Adult
  • Purity: >99%
  • Assay: 100.3%
  • Shipping Method: Hkems, DHL, TNT, Etk, Eub, FedEx
  • Transport Package: Customized
  • Origin: China
  • Powder: Yes
  • Certification: GMP, ISO 9001, USP
  • State: Powder
  • Name: Domperidone
  • Package Time: Within 6 Hours
  • Trademark: JCJ
  • Specification: USP
  • HS Code: 123456
Product Description
Basic information:

Chemical name:Domperidone
MF: C22H24ClN5O2
MW: 425.91
CAS: 57808-66-9
MOQ: 10g
Appearance: White to light yellow powder
Delivery methods: By express
Delivery time: 4~7 working days


Product description:
 
Domperidone is a kind of potent peripheral dopamine receptor antagonist with anti-vomiting and gastro-kinetic effects. It can affect the gastrointestinal motility to make the motility and tension of upper gastrointestinal tract return to normal and promote gastric emptying, enhancing the antral and duodenal motility, and coordinating the pyloric contraction. It can be used for the treatment of dyspepsia, and the nausea and vomiting induced by functional, organic, infection, dietary, radiation therapy or drug therapy. Because it almost has no inhibitory effect on dopamine receptor, there are no psychiatric and neurological side effects. And it can be used for treating the nausea caused by treating the Parkinson's disease through taking dopamine agonists. It can be used as anticholinergic antispasmodics.
 
Product  Application:
COX2 inhibitor, antiinflammatory, antiarthritic .
A novel peripheral dopamine receptor antagonist that does not cross the blood-brain barrier; anti-emetic. Domperidone(Motilium) is a dopamine blocker and an antidopaminergic reagent.
 For management of dyspepsia, heartburn, epigastric pain, nausea, and vomiting.


COA:
 
ItemsStandardResults
AppearanceWhite or almost white powderConforms

Identification
A.Thin-layer chromatography
B. IR spectrophotometry

Rf value of the principal spot observed in the chromatogram of test solution corresponds to that of the pricipal spot observed in the chromatogram of standard solution
IR spectrum of omeprazole sample corresponds to that of omeprazole RS.

Conforms
 
Conforms
Completeness of solutionClearConforms
Color of solutionThe absorbance at 440 nm is not greater than 0.100.01
Loss on drying≤0.5%0.03%
Residue on ignition≤0.1%0.09%
Heavy metals0.002%<0.002%
Residual solvents
Methylene chloride
Methanol
Acetone 
≤600ppm
≤3000ppm
≤5000ppm
76ppm
164ppm
130ppm
Chromatographic purity
Any individual impurity
Total impurities
≤0.3%
≤1.0%
0.04%
0.11%
Microbial limits
Bacteria
Total molds and yeasts
Controlled bacteria
≤500 CFU/g
≤50 CFU/g
Absence
<10 CFU/g
<10 CFU/g
Undetectable
Assay98.0%-102.0%100.9%
Partical size ≥85%(≤15um)96.1%
ConclusionConforming to USP 36 and in-house requirements.        .



Increased rate of gastric emptying
The active ingredient in Domperidone is domperidone. Domperidone works by tightening the muscles at the entry to the stomach and relaxing the muscles at the exit of the stomach. These actions speed up the passage of food through the stomach into the intestine, which physically helps prevent vomiting and reduces feelings of sickness.

Control of the vomiting reflex
Domperidone also blocks or reduces stimulation in an area of the brain known as the vomiting centre by suppressing nerve messages from the gut or preventing them from being sent. This reduces the sensation of nausea and prevents vomiting.

Domperidone is available in tablet, suspension and suppository form. Domperidone tablets only take 15 to 30 minutes to take effect and their effect will wear off after six to eight hours. Domperidone suppositories provide relief in just one to two hours.


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