Nootropic Agent Coluracetam CAS: 135463-81-9 Cognitive Enhancer
|FOB Price:||US $1 / g|
|Min. Order:||10 g|
|Min. Order||FOB Price|
|10 g||US $1/ g|
|Payment Terms:||T/T, Western Union, Money Gram|
- Model NO.: 135463-81-9
- Customized: Customized
- Suitable for: Adult
- Purity: >99%
- Appearance: White Crystalline
- Export Market: Global
- Trademark: JCJ
- Specification: usp
- HS Code: 456789
- Powder: Yes
- Certification: GMP, ISO 9001, USP
- State: Powder
- CAS: 135463-81-9
- Color: White
- Usage: Nootropic Agent
- Transport Package: Customized
- Origin: China
Chemical name: COLURACETAM, MKC-231
Appearance: White powder
What is Coluracetam?
Coluracetam, as known as MKC-231 has been classed as a nootropic agent. It's known to enhance cognitive effects, based on the ways in which it influences choline uptake. Originally developed to treat Alzheimer's disease, Coluracetam was found to be more effective as a nootropic and is purely marketed as a cognitive enhancer.
It is one of the newer racetam nootropics to reach the market. Since Coluracetam enhances levels of choline in the brain and body, it increases the production of acetylcholine. Without acetylcholine, we wouldn't be able to remember the simplest of facts or move our muscles. It's been reported that Coluracetam not only increases acetylcholine levels but also speeds up its flow.
Benefits and Effects:
After acquiring the license from Mitsubishi Tanabe Pharma Corporation, BrainCells Inc. immediately began testing the effects of coluracetam. As there weren't enough participants to take part in clinical trials for coluracetam, most of these tests were conducted on rats instead. From these tests, coluracetam was shown to markedly improve memory, learning, and anxiety.
Memory and Learning
Coluracetam is shown to improve cognitive function and memory in rats, and in theory, the same results are expected in human beings. A study conducted by BrainCells Inc showed a memory improvement in rats who were given substance AF64A (a neuron-specific neurotoxin) for eight days along with coluracetam in 3 mg doses. They were then put through the standardized Morris Water Maze to mark their ability to get through it, and even up to 72 hours after the last 8 mg dose, they were still able to. Another key finding of this study was that the results were still apparent three days after the last dose, even though the serum concentration of coluracetam was negligible.
Depression and Anxiety
BrainCells Inc. found that a dosage of 240 mg (split into three daily doses of 80 mg) was useful in treating major depression with co-morbid GAD (generalized anxiety disorder). However, the differences were most pronounced in those who didn't find relief in using standard antidepressants. After one dose, there were no noticeable differences, but after two doses of 80 mg, 36% had improved scores during a depression assessment test.
How it works?
Like most racetam compounds, coluracetam increases choline uptake, but it also increases uptake in damaged neurons. Specifically, coluracetam interacts with the HACU process, which is responsible for absorbing choline into the neurons. This increased uptake occurs during the acetylcholine synthesis process.
Since coluracetam improves choline preservation during this process, a larger amount is converted into acetylcholine. This process results in increased memory, attention, and alertness. It is important to note here, that these benefits were only seen in subjects with previously impaired neurons, not in subjects with normally functioning neurons.
Coluracetam is also shown to improve AMPA potentiation, which is a process that triggers cognitive function and alertness.
Although coluracetam interacts with choline transporters as well, there isn't enough evidence to explain why or how this interaction occurs, or what occurs after the interaction.
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|Outer Packing||1kg/foil bag|
|Production date||2017.06.26||Shelf life||2 years|
|Standard adopted|| |
In-house quality standard
|Items of analysis||Specification||Results|
|Appearance||White crystalline powder||Conforms|
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