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Supplier Homepage Product Veterinary Raw Material Factory Supply Veterinary Material Praziquantel CAS55268-74-1

Factory Supply Veterinary Material Praziquantel CAS55268-74-1

FOB Price: US $1 / g
Min. Order: 10 g
Min. Order FOB Price
10 g US $1/ g
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Port: Shenzhen, China
Production Capacity: 1000kg/Month
Payment Terms: L/C, T/T, D/P, Western Union, Paypal, Money Gram

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Basic Info
  • Model NO.: Praziquantel
  • Delivery: 3-5 Business Days
  • Supply Ability: Mess in Stock
  • MOQ: 10g
  • Molecular Formula: C19h24n2o2
  • Transport Package: Customized
  • Origin: China
  • Shipping Time: 1 Day for Ready Goods
  • Shipping Method: DHL, FedEx, TNT, Hkems, EMS Express
  • Payment: T/T, Western Union, Money Gram, Paypal, Bitcoin
  • CAS: 55268-74-1
  • Trademark: Oxfendazole
  • Specification: ISO9001, White Crystalline Solid
  • HS Code: 846321864
Product Description
Praziquantel
Product Name: Praziquantel
Synonyms: 1-a]-isoquinolin-4-one,2-(cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-4H-pyrazino-[2;2-cyclohexylcarbonyl-1,2,3,6,7,11b-hexahydro-4h-pyrazino(2,1-a)isoquinolin-4;4h-pyrazino(2,1-a)isoquinolin-4-one,2-(cyclohexylcarbonyl)-1,2,3,6,7,11b-hexah;4H-pyrazino-[2,1-a]-isoquinolin-4-one,2-(cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-;biltricide;droncit;embay8440;praz,quantel
CAS: 55268-74-1
Assay: 99%
Packing: 25kg/drum
MF: C19H24N2O2
MW: 312.41
EINECS: 259-559-6
Appearance: White or almost white crystalline powder
 
Praziquantel Basic information
The treatment of schistosomiasis Chemical Properties Application Production method Category Toxicity grading Acute toxicity Flammability and hazardous characteristics Storage Characteristics Extinguishing agent
Product Name:Praziquantel
Synonyms:1-a]-isoquinolin-4-one,2-(cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-4H-pyrazino-[2;2-cyclohexylcarbonyl-1,2,3,6,7,11b-hexahydro-4h-pyrazino(2,1-a)isoquinolin-4;4h-pyrazino(2,1-a)isoquinolin-4-one,2-(cyclohexylcarbonyl)-1,2,3,6,7,11b-hexah;4H-pyrazino-[2,1-a]-isoquinolin-4-one,2-(cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-;biltricide;droncit;embay8440;praz,quantel
CAS:55268-74-1
MF:C19H24N2O2
MW:312.41
EINECS:259-559-6
Product Categories:Pharmaceutical;API;Cosmetic Ingredients & Chemicals;API's;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;BILTRICIDE;Antiparasitic
Mol File:55268-74-1.mol
 
 
Praziquantel Chemical Properties
mp 136-138 C
storage temp. −20°C
Merck 13,7802
EPA Substance Registry System4H-Pyrazino[2,1- a]isoquinolin-4-one, 2-(cyclohexylcarbonyl)-1,2, 3,6,7,11b-hexahydro-(55268-74-1)
 
Safety Information
Hazard Codes F,C
Risk Statements 11-34
Safety Statements 16-26-36/37/39-45
WGK Germany 1
RTECS UQ4150000
 
MSDS Information
ProviderLanguage
2-Cyclohexyl-carbonyl-1,3,4,6,7,11b-hexahydro-2H-pyrazine(2,1-a)isoquinoline-4-oneEnglish
SigmaAldrichEnglish
 
Praziquantel Usage And Synthesis
The treatment of schistosomiasisSchistosomiasis is parasitic disease with both human and animal being prone to get infected. Schistosome has a relative complicated life history. Adult parasites live in the mesenteric vein and portal vein blood of people, cattle, pigs and some other mammals, and therefore humans and these animals are called as the adult host or definitive host. 
Praziquantel is a kind of common drugs for treatment of schistosomiasis with an extremely small animal toxicity. After its oral administration, it is rapidly absorbed in the digestive tract. The time of the plasma concentration for reaching peaks: 5 minutes for mice, l5 ~ 30 minutes for rat, 30 to 120 minutes for dogs, and 2 h for sheep. After its absorption this drug is widely distributed in all tissues and organs; it is even able to penetrate through the blood-brain barrier of rats and can also enter into the bile of dogs. It can induce of influx of the Ca 2+ located outside of the schistosome parasite muscle cell membrane, and thus causing muscle contractures and loss of ability of sucking parasite location. At the same time, it also causes deficiency in sugar metabolism and energy metabolism, disrupting the "With immunization" state and then working together with the host immune system for finally eliminating the parasites. Therefore, it has good killing efficacy in treating China branch schistosomiasis, tapeworm, lung fluke, cysticercosis and also immature parasites (cercariae and miracidia). 
The common side effects of praziquantel are as follows: 
1. during the first 1 hour of medication of the first time: dizziness, headache, nausea, abdominal pain, diarrhea, fatigue, aching limbs can occur, usually at a lesser extent and short duration, and does not affect the treatment without specific treatment. 
2. in a few cases, there may be symptoms such as heart palpitations, chest tightness, and T wave change and primary contraction in ECG; supraventricular tachycardia and atrial fibrillation can sometimes also happen.
3. in a few cases there may be a transient increase in transaminases and toxic hepatitis.
4. it sometimes can induce mental disorders and gastrointestinal bleeding.
5. hernia, allergic reactions (rash, asthma), etc. are also seen.
Chemical PropertiesIt is white or almost white crystalline powder; it is odorless with a slightly bitter taste. It also has hygroscopic effect. Solubility (g/100m1): 9.7 in ethanol, 56.7 in chloroform, and 0.04 in water. It is easily soluble in dimethyl sulfoxide (DMSO), but insoluble in ether. It has a melting point of 136 ~ 141 ºC. Acute toxicity LD50 in mice and rats (mg/kg): 2000 ~ 3000 oral administration,> 3,000 subcutaneously injection.
ApplicationIt is a kind of broad-spectrum anti-parasitic disease drug. It can be used for the treatment and prevention of schistosomiasis, cysticercosis, paragonimiasis, hydatid disease, fasciolopsiasis, hydatid disease, and worm infection. 
It can also be used as anthelmintic and is effective in treating animal gastrointestinal nematodes. It can be mixed in the feed for application. 
The product is a kind of anthelmintic drug effective in treating Schistosoma japonicum, Schistosoma mansoni and Schistosoma haematobium, Clonorchis sinensis, Paragonimus westermani, fasciolopsis buski, tapeworms and cysticercosis. It has a especially strong killing effect on tapeworm and is currently of highest efficiency among anti-schistosomiasis drug. 
It is a kind of anthelmintics drug mainly used for treating schistosomiasis. It can also used for treating Fahrenheit schistosomiasis, taeniasis, paragonimiasis, and cysticercosis
Production methodThere are a variety of synthetic routes (isoquinoline route, piperazine route, and phenethylamine route). Isoquinoline has advantages such as wide sources of initial raw material and low cost. Isoquinoline can be converted to 1-benzoyl-2-cyano-1,2-dihydro-isoquinoline through Reissetr reaction. It is further converted to 1-benzoyl-aminomethyl-1, 2, 3, 4-tetrahydroisoquinoline through pressurized hydrogenation. Then followed by cyclization with chloroacetyl chloride to give 2-benzoyl-1,3, 4,6,7,11b-hexahydro-2H-pyrazino[2,1-b]isoquinolin-4-ketone. Finally, apply phosphoric acid hydrolysis and perform condensation reaction with cyclohexanecarboxylic acid chloride to obtain the final product. 
There are a variety of synthetic routes for industrial production including isoquinoline route, piperazine route, and phenethylamine route, among which the isoquinoline route is the best. In this route, first perform adduct reaction between isoquinoline and benzoyl chloride as well as potassium cyanide, further go through catalytic hydrogenation and rearrangement to generate 1-benzoyl-methyl-amino-1,2,3,4-tetrahydroisoquinoline, and then sequentially go through chlorine acetylation, cyclization, hydrolysis under increased pressure, and cyclohexanone acylation to generate the final product. 
Take phenethylamine as the raw material, after acylation through chloroacetyl chloride, further introduce the amino group after adding terephthalamide potassium for amination reaction, then have cyclization reaction in the action of phosphorus oxychloride to give 3,4-dihydroisoquinoline derivative; further go through hydrogenation and hydrolysis to obtain 1-aminomethyl-tetrahydroquinoline; successively use cyclohexane carboxylic acid chloride and chloroacetyl chloride for acylation and finally go through dehydrochlorination and cyclization to obtain praziquantel.
You can alternatively use isoquinoline as raw material; it first go through Reissert reaction to introduce a cyano group in l position and have nitrogen benzoylated, followed by hydrogenation while benzoyl group is transferred to the amino group of the side chain, further introduce a chlorine acetyl group to the amino group on the ring, then successively go through cyclization, hydrolysis, cyclohexanone formylation to obtain praziquantel.
The above information is edited by the chemicalbook of Dai Xiongfeng.
CategoryToxic substances
Toxicity gradingPoisoning
Acute toxicityOral rat LD50; 2840 mg / kg; Oral - Mouse LD50: 2454 mg / kg.
Flammability and hazardous characteristicsCombustible; combustion produces toxic fumes of nitrogen oxides.
Storage Characteristicsventilation, low-temperature, and drying.
Extinguishing agentDry powder, foam, sand, carbon dioxide, water spray.
Chemical PropertiesWhite Solid
Usageanthelmintic; EMBAY-8440
UsageAnthelmintic, effective against flatworms.
 
Praziquantel Preparation Products And Raw materials
Raw materialsAcetyl chloride-->1,4-Diazacyclohexane-->POTASSIUM CYANIDE-->Benzoyl chloride-->Chloroacetyl chloride-->Isoquinoline-->Cyclohexanecarboxylic acid chloride-->3,4-DIHYDROISOQUINOLINE-->Pyrazine-->oxazine

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LGD-4033  Competitive Advantage:
 
Company Competitive Advantage: 
1. Rich experiences.Our company is a professional production leading factory in China in pharmaceutical area of many years. Delivery areas of our products:US, UK, Canada, Australia, Brazil, Russia, Portugal, Latvia, Switzerland, Iceland, Ukraine, Germany, France, Netherlands, Belgium, Peru, Sweden, New Zealand, the Czech Republic, Lithuania, Ireland, Tunisia, Mexico, Greece, Puerto Rico, Thailand, Israel and so on,and we have got very good feedback from our customers, we had established a long friendly relations
Payment method: T/T, Western union, Moneygram

2. Discreet package
The packing suits you best would be choosen to cross customs safely. Or if you have your own ideal way, it could be also take into consideration .
3. Top quality.High quality guarenteed, once any problem is found, the package would be reshipped for you
4. Security ShippingShipping by express (FedEx,UPS,DHL,EMS), by air.The most professional forwarder would be recommanded for you.
5,Shipping timeWe have stock, so we can delivery quickly at the very day when receive the payment.
6,ServiceWarm after-sale service for you 24/7. Any of your question would be solved for the first as soon as possible.Adhering to the principle of customer first conviction.we will provide the best and the most sincere services as possible as we can.
7. High qualityHigh quality, best price, first-class service, high successful delivery rate .A discount would be given when you make a large order.


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Frequently Asked Questions:

Question 1 , How do you pack the order ?

                Discreet package , the packing suits you best would be choosen to cross

customs safely

Question 2, What is your shipping method

                  Shipping by express (FedEx,UPS,DHL,EMS,HKEMS,TNT), and cheapest by airmail

 Question 3, if my order seized by custom ,what do you do ?
                       
                   Resending police if the tracking number do not update online or it sezied by custom

   Questions 4, What is your payment accept
 
                     Safe and fast payment : Western Union ,Money Gram ,T/T ,Bitcoin

     Questions 5, Will you supply tracking number 
             
              Yes ,we supply tracking number for following . In general ,once we supply the tracking number to you ,you can track the parcel information within 1-2 business days 

    Question 6, How many times will it take to my country after I do the payment

             In general ,fastest with 3-5 business , slowest 5-7 business days 



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