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Wuhan JCJ Logis Co., Ltd.

Tenofovir, Tenofovir 99%, Anti-HIV manufacturer / supplier in China, offering 99% Tenofovir Used as an Anti-HIV Agent Manufacturing, Oral Anabolic Steroid Methyltrienolone 965-93-5 Metribolon Acetate Anti Estrogen, Legit Steroid Estrogen 99% Tibolone Acetate Livial Muscle Gainning Weight Loss and so on.

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Supplier Homepage Product Pharmaceutical APIs Raw Material 99% Tenofovir Used as an Anti-HIV Agent Manufacturing

99% Tenofovir Used as an Anti-HIV Agent Manufacturing

Purchase Qty.:
(grams)
10-99 100+
FOB Unit Price: US $1 US $10
Purchase Qty. (grams) FOB Unit Price
10-99 US $1
100+ US $10
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Port: Shenzhen, China
Production Capacity: 1 Ton Per Month
Payment Terms: T/T, Western Union, Money Gram, Bitcoin

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Basic Info
  • Model NO.: 99% Tenofovir
  • CAS: 147127-20-6
  • Assay: 99%
  • Grade: Pharmaceutical Grade
  • Payment Methods: T/T; Western Union; Money Gram; Bitcoin
  • Transport Package: Customized
  • Origin: China(Mainland)
  • Suitable for: Adult
  • Mf: C9h14n5o4p
  • Packages: Customized
  • Delivery Time: Within 3-7 Days After Payment
  • Trademark: JCJ Create
  • Specification: powder
  • HS Code: 8575448945
Product Description
Tenofovir Basic information
Antiviral drugs Pharmacokinetics Indications Preparation Adverse effects
Product Name:Tenofovir
Synonyms:1-(6-aminopurin-9-yl)propan-2-yloxymethylphosphonic acid;D,L-TENOFOVIR;TENOFOVIR;(R)-9-(2-PHOSPHONYLMETHOXYPROPYL)-ADENINE;(R)-9-(2-Phosphonomethoxypropyl)Adenine;Tenofovir(ForResearchOnly);(R)-PMPA;[[(1R)-2(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]phosphonic Acid
CAS:147127-20-6
MF:C9H14N5O4P
MW:287.21
EINECS: 
Product Categories:Purine;ACTIVE PHARMACEUTICAL INGREDIENTS;Nucleotides and Nucleosides;Bases & Related Reagents;Intermediates & Fine Chemicals;Nucleotides;Pharmaceuticals;Phosphorylating and Phosphitylating Agents
Mol File:147127-20-6.mol
 
 
Tenofovir Chemical Properties
mp 276-280°C
storage temp. Store at -20°C
Water Solubility 13.4 mg/mL (25 ºC)
CAS DataBase Reference147127-20-6(CAS DataBase Reference)
 
Safety Information
 
MSDS Information
 
 
Tenofovir Usage And Synthesis
Antiviral drugs 
Tenofovir is an acyclic nucleoside antiviral reverse transcriptase inhibitor. The active substance is Tenofovir disoproxil, while tenofovir is a prodrug that is used because of its better absorption in the gut.
Tenofovir can inhibit viral polymerase through direct competitively combine with natural deoxyribose or by insertion to terminate chain of human DNA. It is the first nucleotide analogs to treat HIV-1 infection that approved by the US Food and Drug Administration (FDA).
Tenofovir is a main medicine in AIDS cocktail therapy, researches has shown that it can effectively improve the monkeys` ability on prevention of immunodeficiency virus (similar to the human AIDS virus).
The above information is edited by the Chemicalbook YangDongmei.
PharmacokineticsTenofovir is hardly absorbed through the gastrointestinal tract, for this reason, prodrug of Tenofovir has been developed by esterification, and then to make tenofovir fumarate ester. Tenofovir ester is water-soluble, can be rapidly absorbed and degraded into the active tenofovir, and then was metabolized to the active Tenofovir disoproxil. Tenofovir will reach the peak of plasma Concentration within 1-2 h after administration. When combined with food service, the bioavailability of Tenofovir can be increased by 40%. Intracellular half-life of Tenofovir disoproxil is about 10 h, it needs dosing everyday. Because Tenofovir is not a CYP-450 substrate, this may decrease the possibility of interactions with other drugs caused by CYP450. Elimination of Tenofovir is by glomerular filtration and active tubular secretion. Approximately 70% to 80% is recovered in urine as unchanged drug. Elimination half-life is approximately 17 h.
IndicationsTenofovir is indicated for the treatment of HIV, HBV infection. This product also can cooperated with other reverse transcriptase inhibitors for HIV-1 infection and hepatitis B treatment.
Preparation 
Adverse effects1.The most common side effects associated with Tenofovir include asthenia.
2.Tenofovir has also been implicated in mild to moderate gastrointestinal reactions such as nausea, vomiting, diarrhea, and asthenia. Less frequent side effects include hepatotoxicity, abdominal pain, and flatulence,bloating, lactic acidosis, hepatomegaly with fatty liver, pancreatitis and so on. these adverse effects are common with the use of nucleoside analogues either separately or when combined with other drugs.
3.Tenofovir can also lead to metabolic system hypophosphatemia (1% incidence); fat accumulation and redistribution, including central obesity, buffalo hump, peripheral wasting, breast enlargement, Cushing syndrome.
4.Tenofovir may cause lactic acidosis, hepatomegaly with steatosis-related and so on.
5.Tenofovir may make nervous system: dizziness, headache.
6.Tenofovir sometimes leads to respiratory system: dyspnea.
7.Tenofovir may cause skin herpes.
Chemical PropertiesWhite Crystalline Solid
UsageAcyclic phosphonate nucleotide analogue. Used as an anti-HIV agent
UsageAcyclic phosphonate nucleotide analogue; reverse transcriptase inhibitor. Used as an anti-HIV agent. Antiviral.
UsageTenofovir blocks reverse transcriptase and hepatitis B virus infections.
Biological ActivitySelectively inhibits HIV reverse transcriptase (RNA-dependent DNA polymerase). Prevents cytotoxicity in SIV-infected C-8166 cells in vitro (IC 50 = 1.5 μ M). Antiviral agent.



Packaging & Delivery.
1. Sufficient Stock
2. Sophisticated and professional logistic agent.
3. Well-trained and disciplined packing team. Unique packing ways to ship 10g to 20kg for higher customs clearance.
4. Packing pictures and Tracking No. are provided within 24 hours after payment.
5. After-sale service

Competitive Advantage:
1. Rich Experiences.
Our company has been dealt in the pharmaceutical manufacturing area for many years. Delivery areas of our products extend all around the world. we have got very good feedback from our customers of worldwide, we had established a long friendly relations and enjoyed a high reputation both at home and abroad.
Payment method: T/T, Western Union, Money Gram.
2. Discreet package.
The package suits you best would be chosen to get through customs security smoothly Or Customized if you want.
3. Superior quality and Reasonable price.
High quality guaranteed, once any problem is found, the goods would be reshipped for you.
4. Security Shipping.
Shipping by express (FedEx,UPS,DHL,EMS) or by air. The most professional forwarder would be recommended for you.
5. We have stock.
We can delivery goods promptly at the same day after confirming the payment.
6. Discounts
We will do some promotion at the specific time, we would inform you anytime if we have sorts of discount activities. We can give you some discounts if you order a large number of goods.
7. Warm after-sale service for you 24/7.
Any of your question would be solved for the first time asap. We will provide the best and the most sincerest services for your satisfaction.
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