|Indometacin Basic information|
|Synonyms:||AURORA KA-6542;INDOCIN;INDOMETACIN;INDOMETACINE;INDOMETHACIN;INDOMETHACINE;LABOTEST-BB LT00244830;1-(P-CHLOROBENZYL)-5-METHOXY-2-METHYLINDOLE-3-ACETIC ACID|
|Product Categories:||PHARMACEUTICALS;Active Pharmaceutical Ingredients;All Inhibitors;Inhibitors;Intermediates & Fine Chemicals;Lipid signaling;INDOCIN;Other APIs;Pharmaceutical raw chemicals|
|Indometacin Chemical Properties|
|mp ||155-162 °C|
|storage temp. ||Store at RT|
|solubility ||ethanol: 50 mg/mL, clear, yellow-green|
|Stability:||Stable. Incompatible with strong oxidizing agents.|
|CAS DataBase Reference||53-86-1(CAS DataBase Reference)|
|NIST Chemistry Reference||Indomethacin(53-86-1)|
|EPA Substance Registry System||1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy- 2-methyl-(53-86-1)|
|Hazard Codes ||T+,Xi,T|
|Risk Statements ||28-36/37/38-39/23/24/25-23/24/25|
|Safety Statements ||28-36/37-45-36-26|
|RIDADR ||UN 2811 6.1/PG 1|
|WGK Germany ||3|
|Hazardous Substances Data||53-86-1(Hazardous Substances Data)|
|Indometacin Usage And Synthesis|
|Chemical Properties||Crystalline Solid|
|Usage||Inhibits cyclooxygenase (IC50=0.1uM) selectively over liposygenases (IC50=100uM for 5-,12- and 15-LO). A clinically useful NAISD|
|Usage||antiinflammatory, antipyretic, analgesic|
|Air & Water Reactions||Practically insoluble in water. Decomposes in alkali.|
|Reactivity Profile||A weak organic acid.|
|Fire Hazard||Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated.|
|Biological Activity||Cyclooxgenase (COX) inhibitor; displays selectivity for COX-1 (IC 50 values are 230 and 630 nM for human COX-1 and COX-2 respectively). Widely used anti-inflammatory agent.|
|Indometacin Preparation Products And Raw materials|
|Preparation Products||Acemetacin-->indomethacin farnesil|
|Raw materials||p-Anisidine-->Levulinic acid-->4-Chlorobenzoyl chloride|
Packaging & Delivery.
1. Sufficient Stock
2. Sophisticated and professional logistic agent.
3. Well-trained and disciplined packing team. Unique packing ways to ship 10g to 20kg for higher customs clearance.
4. Packing pictures and Tracking No. are provided within 24 hours after payment.
5. After-sale service
1. Rich Experiences.
Our company has been dealt in the pharmaceutical manufacturing area for many years. Delivery areas of our products extend all around the world. we have got very good feedback from our customers of worldwide, we had established a long friendly relations and enjoyed a high reputation both at home and abroad.
Payment method: T/T, Western Union, Money Gram.
2. Discreet package.
The package suits you best would be chosen to get through customs security smoothly Or Customized if you want.
3. Superior quality and Reasonable price.
High quality guaranteed, once any problem is found, the goods would be reshipped for you.
4. Security Shipping.
Shipping by express (FedEx,UPS,DHL,EMS) or by air. The most professional forwarder would be recommended for you.
5. We have stock.
We can delivery goods promptly at the same day after confirming the payment.
We will do some promotion at the specific time, we would inform you anytime if we have sorts of discount activities. We can give you some discounts if you order a large number of goods.
7. Warm after-sale service for you 24/7.
Any of your question would be solved for the first time asap. We will provide the best and the most sincerest services for your satisfaction.